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Abstract Regenerative medicine encompasses new emerging branch of medical sciences that involves the functional restoration of tissues or organs caused by severe injuries or chronic diseases

Both randomized controlled trials (RCTs) and non-RCTs, such as observational or cohort studies, were considered

This leads to the activation of p53-, p21- and p16-dependent canonical senescence pathways, further impeding liver regeneration

Tier 1, 2 and 3 benchmarks will align with the NCQA Quality Compass 66.67th, 75th and 90th percentiles, respectively

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