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Berberine (BBR) is a natural isoquinoline alkaloid 16 that has several significant pharmacological effects, including antibacterial 17 , antiviral 18 , anti-inflammatory 19 , and anticancer properties 20

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On April 30, 2026, the FDA proposed to exclude semaglutide, tirzepatide, and liraglutide from the 503B bulks list entirely, citing no clinical need for large-scale compounding now that FDA-approved supply is stable