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In men, significant weight loss from these agents may improve obesity-related hypogonadism, testosterone levels, and cardiovascular risk factors

GLP-1Rs agonists exert neuro-humoral actions by stimulating insulin secretion and suppressing glucagon release in a glucose-dependent manner, delaying gastric emptying, and reducing appetite via central nervous system pathways

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Marketing authorisation holders should also consider implementing awareness campaigns on weight management and educational activities on the ongoing shortage and its implications for clinical practice