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(ALT)(Acetaminophen) product: It may be useful to predict hepatotoxicity, especially after chronic ingestion or with delayed admission

Perhaps the reason is that those drugs do not cross the bloodbrain barrier, Hlscher suggested

Food intake data were collected on a continuous basis from 24 h before dosing (allowing for replenishment of food as well as dosing time) and throughout the study

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"International Non-Proprietary Name for Pharmaceutical Preparations (Recommended List #4)" (PDF)