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doi: 10.1073/pnas.2009201117 27 KraftVANBezjianCTPfeifferSRingelstetterLMullerCZandkarimiFet al

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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by pyruvate dehydrogenase and therefore that TCA cycle flux is diminished (Gray et al., 2015

134,135 Phase 2b and phase III clinical studies have revealed that mTOR inhibitors (RTB101) can improve the immune capacity of the elderly