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The stated basis was insufficient safety and efficacy data to support compounding

Kaliannan et al

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In skin, GHK-Cu signals fibroblasts to produce collagen, modulates matrix metalloproteinases for balanced tissue remodeling, and triggers expression changes in approximately 31 percent of human genes toward a younger profile 1 9

Further, the presence of metabolites related to purine metabolism and the urea cycle in females could reflect a heightened sensitivity to disruptions in nitrogen metabolism, which may contribute to differences in how females experience and adapt to GH deficiency over time