20 However, GLP-1RAs have less profound effects on reduction of hospitalisations for heart failure and renal protection than SGLT-2 inhibitors
Furthermore, these mice exhibited an altered expression of the Cl transporter KCC2 in the amygdala, which influences GABAergic signal pathways [516]
On one hand, they are counteracting the SGLT2 inhibitors associated rise in EGP and glucagon, on the other hand, they are potentially applying an additive or synergistic effect on RAAS blocked and glucose-lowering to delay the progression of DKD [17]
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