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It affects an estimated 160 million people worldwide, with women being 710 times more susceptible than men

"Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells"

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Although different TLRs recognize distinct ligands, all TLRs share a conserved cytoplasmic domain named Toll/interleukin (IL)-1 receptor (TIR) domain, which mediates downstream signaling by recruiting specific adaptor proteins, including TIR domain-containing adaptor molecules to receptors