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This mechanism is central to how GLP-1 drugs reduce appetite and support weight loss
Class-related safety considerations include pancreatitis, gallbladder disease, increased heart rate, and a precautionary contraindication in patients with a history of medullary thyroid carcinoma or MEN2
The UK Summary of Product Characteristics (SmPC) for Mounjaro and the British National Formulary (BNF) list no interactions between tirzepatide and antidepressants, including SSRIs like sertraline
Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, et al
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