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These solutions are chloride-free (or low chloride) to enable chloride shift (influx of the weak acid bicarbonate in exchange for the efflux of the strong chloride)

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A 2017 meta-analysis found that ALA supplementation led to an average weight loss of 1.27 kg (2.8 lbs) and a BMI reduction of 0.43 kg/m compared to placebo

Participants taking liraglutide also achieved a 5.5% total body weight change compared with placebo over the 48-week study period

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