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Combined, these studies involved fewer than 30 human subjects and lacked control groups none used a randomized, placebo-controlled design

2016 doi: 10.1155/2016/9352598

doi:10.1016/j.pdpdt.2020.102070 Dougal G, Lee SY

34 linked pagesOpen original fda-gram-peptides-warning-2026 PCO-02 safety and pharmacokinetics trial ClinicalTrials.gov Primary regulatory Dec 22, 2015 accessed Jul 12, 2026 Registry record for a Phase 1 safety and pharmacokinetics study associated with BPC-157

The logic is compelling - a naturally occurring stomach-protective compound applied to gut healing - but human studies haven't yet validated these effects in real patients with conditions like leaky gut, IBS, or inflammatory bowel disease