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Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)

Another protein with extensive connections is sequestosome-1 (SQSTM1), which interacts with 18 proteins, might play a critical role in apoptosis process

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Ginger supplements (12g daily), vitamin B6 (2550mg daily), and antihistamines like meclizine are safe to combine with cagrilintide

10.3389/fimmu.2023.1030198 100 ZhangH.WangK.ZhaoH.QinB.CaiX.WuM.et al (2025a)

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