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In the intestine and brain, PC1 converts proglucagon to the incretin hormones, glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2)

This peptide, made of only 15 linked amino acids, was originally derived from stomach tissue

Some individuals achieve excellent results at 4mg or 8mg and never need to increase to the maximum dose

Based on early-stage development information: While regulatory approval and large clinical trials will determine its final role in treatment, investigational oral GLP-1 medicines like ZYOG1 represent the next phase in metabolic therapy

Osmotic pumps filled with PBS were used as controls

10.1016/s0006-8993(10)80047-2 53 HermansS