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Cleared by FDA

Previous studies pointed that astrocytic -synuclein deposition initiates the recruitment of phagocyte microglia that attacks and kills neurons in restricted brain regions [7,19], correlating this -synuclein accumulation with nigral neuronal cell death [20], and suggest the importance of astrocytes in the initiation of the disease

, Kumar, S

Released Cyt C requires cytosolic GSH levels to be depleted for its pro-apoptotic action [128]

Methadone , a full opioid agonist, has decades of evidence supporting its effectiveness, particularly in cases of high-severity opioid dependence

Since each method typically provides unique information about a specific properties of a protein over different timescales and length scales, the use of such multiparametric approach allows avoiding five blind men and elephant situation (this analogy is based on the ancient parable of the blind men and an elephant, where each person feels a different part of the animal and comes to a completely different conclusion about what an elephant is) (Uversky, 2015a)