semaglutide for obesity 50 mg of oral #semaglutide daily was associated with body weight reduction and improved cardiometabolic risk factors in East Asian adults with overweight or #obesity, with or without type 2 #diabetes. https://ja.ma/41sPiYj Semaglutide from Bench to Bedside:

81,143,144,145 Even though the overexpression of enzymes involved in both the synthesis and breakdown of H 2 S has thus far only been reported for colorectal cancer, 134 it can be envisaged that overexpression of both enzymatic pathways might be a common trait for any cancer type where H 2 S production is increased, as excess H 2 S can become toxic even for the most robust cancer cells (see below)

The financial incentives were enormous: GLP-1 medications generated billions annually, creating powerful motivation to increase prescriptions rather than conduct thorough safety investigations or provide complete risk disclosures

doi: 10.1158/1078-0432.CCR-16-2272 128 SinclairLVNeyensDRamsayGTaylorPMCantrellDA

Faizi M, Salimi A, Rasoulzadeh M, et al

TGF-1 is an important cytokine that induces fibrosis in organs such as the kidneys and lungs [39, 40], and can activate PSCs to induce pancreatic fibrosis [41, 42]

Mostly it does this by removing lactate and transforming pyruvate (a by-product of glucose breakdown) from the enzyme pyruvate dehydrogenase into the energy molecule acetyl-coA, which can then be oxidized for energy production