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Other contributing factors include: Increased stomach acid production due to food staying in the stomach longer

(212), The GM is crucial in regulating both innate and acquired immunity, while simultaneously generating immune intermediates that are indispensable for the development of pro- and anti-inflammatory responses. Figure 4 7.1 Modulation of T cell responses and differentiation The GM is intricately associated with the equilibrium between T helper 17 (Th17) cells and Tregs, suggesting that intestinal bacteria may provoke a disruption in Th17/Treg immunity (213)

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