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Oral, intranasal, and transdermal formulations marketed for these molecules face severe bioavailability challenges

However, it remains challenging to determine the location of the cleaved P i ion as its distance to the nucleotide is not known a priori and its location may fluctuate, causing smearing of the cryo-EM density

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Reconstituted BPC-157 must be stored at 28C and used within 28 days because water reintroduces the hydrolytic pathways that break peptide bonds