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Excessive release of glutamate and its binding with NMDA, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainite (KA) receptors promotes excitotoxicity cell injury with a consequent activation of many molecular pathways, resulting in intracellular calcium (Ca 2+ ) overload 90,91 , reactive oxygen species (ROS) production, mPT, and cell swelling with brain edema 92

The vials should be stored upright in their original containers, protected from light and kept away from the freezer compartment (freezing should be avoided as it may compromise the solution)

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doi: 10.1002/tox.22923 235 DineshPKalaiselvanSSujithaSRasoolM

Most patients find abdomen easiest and least uncomfortable