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Critically, elevated fasting circulating BCAAs in obesity and insulin resistance primarily indicate impaired peripheral catabolic disposal and altered inter-organ flux, not simply excessive dietary intake

10.1016/j.bbrc.2015.08.057 71 ZhouQ.KwanH

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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions