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Alnylams inclisiran, which uses RNA interference to reduce PCSK9 protein expression and thereby lower LDL cholesterol, can be dosed twice yearly versus daily oral statins or biweekly PCSK9 monoclonal antibody injections

Contraindications 10.1 History of Medullary Thyroid Carcinoma Use is contraindicated in individuals with personal or familial history of MTC

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( 2.2) Adults and pediatric patients aged 12 years and older with BBS or POMC, PCSK1, or LEPR deficiency is 2 mg (0.2 mL) once daily for 2 weeks

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Peptide vials should be kept in a cool, dry place to maintain quality