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Most patients have mild skin reactions, while severe (grade 3-4) toxicities are found in a low proportion of patients (5.8% for the ipilimumab + nivolumab combination, even lower values for anti-PD-1 monotherapy), significantly lower than the toxicities of other sites (such as hepatic or gastrointestinal) (129)

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However, some symptoms warrant a trip to the emergency room

Some of the important defense mechanisms in living cells promote the removal of ROS