Energetically, it is not favorable for Arg123 and Arg127 to be too close to each other due to charge-charge repulsion, despite the presence of a negatively charged Glu40 which attracts them
GLP-1 receptor agonists change the way the digestive system functions
Current Pharmaceutical Design, 2011
Mild to moderate symptoms can usually be treated with simple changes, while more serious or long-lasting diarrhea may need medical treatment
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Determination of initial turnover number The initial turnover rates were determined in PBS at pH 7.4 (8 g l 1 NaCl (Labkem, SOCH-00T), 1.44 g l 1 Na 2 HPO 4 (Supelco, 1.06586), 0.2 g l 1 KCl (Panreac, 131494) and 0.24 g l 1 KH 2 PO 4 (Fisher Scientific, BP362)) using ABTS (1 mM), DMP (5 mM), guaiacol (50 mM), sinapic acid (0.35 mM) or p -coumaric acid (0.1 mM) as substrate