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In terms of metabolic parameters, all the treated arms had beneficial changes in their HbA1c%, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, with the Sema+-MSTN+-ActA arm, which showed the largest combination of fat decrease and lean mass increase, showing the biggest beneficial changes (Fig

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Where abnormalities are identified, further evaluation of sex hormone-binding globulin and prolactin is recommended

2 Medical Department III (Endocrinology, Nephrology and Rheumatology), University of Leipzig, Leipzig, Germany