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For example, dermal fibroblasts have membrane expression of Toll-like receptors (TLRs), which actively engage in the bodys defence against invading pathogens and therefore suggest an innate immune role for fibroblasts ( Fibroblasts can also produce a vast array of pro-inflammatory mediators including cytokines, chemokines and growth factors like TNF-, IL-1, IL-6, IL-8, CCL-1, CCL-2, CXCL-5, GM-CSF or G-CSF, leading to the recruitment and activation of immune cells and contributing to processes like angiogenesis, fibrogenesis and modulation of apoptosis resistance

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