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Here are eight takeaways from our conversation with Kessler about using the GLP-1 drugs, and the changing landscape of weight loss

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Feeling drained while on a GLP-1 medication can be frustrating, especially if youre otherwise seeing progress with blood sugar or weight

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Symptoms are getting progressively worse rather than stabilizing

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Retatrutide reduced WOMAC pain scores by up to 4.5 points

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The trial did report a skin-related effect, described as cutaneous hyperesthesia and skin sensitivity, in about 7% of people on retatrutide compared with 1% on placebo, but it did not report alopecia or hair loss as a distinct side effect

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A Dual-Agonist Overview Tirzepatide is a synthetic peptide that acts as a dual agonist of the GLP-1 and GIP receptors

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