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Nutritional deficiencies among the population: vitamin B12 and folic acid deficits are common due to poor diet, vegetarianism, and absorption difficulties, fuelling demand for nutritional supplements

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The second line of defense involves the use of NADPH to reduce GSSG and TrxS2 by TRX, GCL, and glutathione synthetase responsible for GSH synthesis, glutathione reductase, and thioredoxin reductase