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Semaglutide works by mimicking the action of endogenous GLP-1, a hormone that enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
Providers typically price sublingual formulations comparably to or slightly higher than injectable, making the cost per effective milligram significantly higher
Careful dose escalation remains essential, and some patients tolerate one medication better than the other despite their similar mechanisms
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In the UK, hydroxocobalamin is the preferred licensed form for intramuscular injection