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Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe

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Although Woods lamp examination remains useful to determine whether most of the pigmentation is in the epidermis or in the dermis, studies using laser confocal microscopy have demonstrated that all melasma are mixed, suggesting a common pathophysiology [2]

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