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Less muscle means a slower metabolism, which makes keeping weight off in the long term more difficult

It does not directly activate GLP-1 receptors

The physiologic concern is real, and retained gastric contents have been documented

The efficiency of digestion was evaluated and considered acceptable if protein missed cleavage was 10% or lower

Earlier studies, including a 2018 double-blind RCT of 228 adults with functional constipation, found no significant difference between HN019 and placebo in primary outcomes overall, but a post-hoc subgroup analysis in adults with very low baseline stool frequency (fewer than 3 bowel movements per week) showed a physiologically relevant increase in bowel movement frequency in the HN019 groups vs

doi: 10.1002/ajmg.a.37659 94 WaltherD