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The biggest risk factor is taking more than prescribed or using it for non-medical reasons

[8] [9] [10] [11] Although reduced GLP-1 secretion has previously been associated with attenuated incretin effect in patients with type 2 diabetes, further research indicates that GLP-1 secretion in patients with type 2 diabetes does not differ from healthy subjects

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In addition to the two GLP-1 injections, Eli Lilly is working on a weight loss pill

The glucagon component increases metabolic rate, activates brown adipose tissue, and drives fat oxidation all of which are thermogenic processes

GLP-1 receptor agonists pass the bloodbrain barrier and directly engage with GLP-1 receptors in essential appetite-regulating sites of the hypothalamus and brainstem (Trapp and Brierley 2022)