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Ive had patients come to me in a wheelchair, in tears, people who could barely walk because of arthritis in their knee

JAMA 324:879887 Courcoulas AP, Patti ME, Hu B, Arterburn DE, Simonson DC, Gourash WF et al (2024) Long-term outcomes of medical management vs bariatric surgery in type 2 diabetes

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None of this means the peptides are worthless or that future trials won't show benefit

Semaglutide is the active ingredient in Ozempic, Wegovy, and Rybelsus, but the drugs have different approvals and different usages according to the manufacturer and the FDA

Treatment usually starts at a smaller dose that increases incrementally until you reach your maintenance dose