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Free Radical Biology and Medicine 46, 11681176 (2009)

doi: 10.3389/fimmu.2018.01127 101 YangJLinXPanYWangJChenPHuangHet al

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

There is increasing evidence that oxidative stress plays a role in the development of autism [74]

The empty B12 vial can also go into the sharps bin

These requirements add to manufacturing costs and complexity