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Most patients notice reduced appetite and cravings within the first week

Realistic expectations: Stopping GLP-1s may worsen your glucose control initially, and you may need significantly more insulin than you needed before starting GLP-1s

One theoretical concern: aggressive caloric restriction accompanying drug-induced satiety reduction could suppress gonadotropins in women with low body fat reserves

The goal is to reduce avoidable muscle loss and support body composition

doi: 10.1001/jama.2019.22360 57 JankovicJTanEK

The observed molecular weight should match the theoretical mass of retatrutide within the instrument accuracy range