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Even though renal tissue is considered to be a major site for 1,25(OH)VD formation, recent studies demonstrate expression of ( CYP27B1 ) in nonrenal cells and tissues, indicating localized 1,25(OH) 2 VD formation and its tissue-specific paracrine function in different tissues (1)

Furthermore, in bile ductcannulated (BDC) rats, the average recovery rates of total radioactivity in bile, urine, feces, and cage cleaning fluid collected during 72 h after dosing were 9.08% 0.86%, 17.77% 6.35%, 2.73% 0.40%, and 0.91% 0.13%, respectively (Table 8

The official guidance from the FDA and most manufacturers has historically been to use caution or avoid these medications while nursing because there wasn't enough data to prove they were safe

Progress of research on the treatment of depression by traditional Chinese medicine prescriptions

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However, a trial in 216 healthy women (25-50 years old) found little benefit of a multivitamin/mineral supplement