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Plasma long-chain acyl-carnitine species are elevated in patients with NAFLD, obesity and type 2 diabetes, suggesting that more fatty acids can enter the mitochondria, but since there is also an elevation of short-chain acyl-carnitines there might be a defect in the oxidation pathways

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Studies that pretreated mice or rats with HFD for some time and then treated them by adding sodium butyrate dietary supplementation showed significant decreases in body weight and fat mass (118, 128, 131)

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