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Simultaneously, catalytically produced hydrogen peroxide (H 2 O 2 ) activates the protein transient receptor potential melastatin 2 (TRPM2) ion channel, promotes calcium influx, activates macrophages, and induces systemic immune response (Fig

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Classic studies established that TLR activation upregulates VDR and CYP27B1, leading to the production of LL-37 and strengthening antimicrobial defense [240]

Panel A presents the 3D structure and 2D interaction map of ethacrynic acid, a well-established GSTP1 inhibitor

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