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Dihydroartemisinin (DHA) exemplifies this duality: at low concentrations or under specific conditions, DHA can paradoxically increase GPX4 activity by upregulating ATF4 expression, potentially suppressing ferroptosis
Furthermore, our study emphasizes the potential correlation between the immune microenvironment of EMs and disulfidoptosis, suggesting that the investigation of PDLIM1 in the context of endoheterogeneity immunity could open up new avenues for understanding the pathogenesis and progression of EMs
Bashmil et al
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