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Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications

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For AE analyses, participants were considered to be on treatment if any dose of trial product was administered within the previous 49 days

While the sponsor-submitted NMA suggests that oral semaglutide showed superior reduction in hemoglobin A1C and weight in some comparisons, the CADTH clinical review identified limitations with the NMA relating to the evaluation of heterogeneity, which increases uncertainty with the results

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