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Why So Many Tirzepatide (Zepbound) & Semaglutide (Wegovy) Patients Also Need Hormone Replacement Therapy (HRT) And How Treating Both Creates Safer, Faster, Longer-lasting Results Tirzepatide and semaglutide restore the GLP-1 and GIP peptide hormones that control appetite and cravings but they arent the only hormones that determine how quickly or safely you lose weight or whether you KEEP it off