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After filtering to retain participants with information regarding pre-treatment and post-treatment BMI and genotype data passing quality control, we obtained 4,889 participants, of which 3,948 had complete data when incorporating covariates akin to those used in the GWAS

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The EMA classifies it as safe, and adverse effects reported in clinical trials are generally mild and transient

Cartilage progenitor cells

Therefore, in GLP-1R KO mice, compensation mechanisms of other receptors may exist to balance the cAMP-mediated downstream signaling pathway to maintain normal survival and activities of the GLP-1R KO mice

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