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Scientific understanding continues to evolve as additional laboratory and clinical research becomes available

This rapid turnover makes it unlikely that peripheral GLP-1 significantly contributes to endogenous activation of central GLP-1Rs

PMID: 34071596

The main functions of GLP-1 include: Thus, GLP-1 helps the body control blood sugar, appetite, digestion, and fat use by allowing the gut, brain, and pancreas to work together

In this sample population, 15,264 individuals (14%) used GLP-1 agonists, whereas 96,382 individuals (86%) did not use these medications

Doses above this level increase hepatic methionine metabolism byproducts like homocysteine, which at chronically elevated levels is associated with cardiovascular risk