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The most common side effects are gastrointestinal, including nausea, diarrhoea, loss of appetite, and mild abdominal discomfort

The drug, which was originally developed at Karuna Therapeutics, began its development journey as an investigational treatment at Eli Lilly for Alzheimers disease, where its effects on the psychotic symptoms of the disease where discovered

It promotes neuronal growth and differentiation by simulating the action of HGF, which is critical in brain development and repair processes

doi: 10.1007/s11154-023-09805-5 32 van BaakMAPramonoABattistaFBeaulieuKBlundellJEBusettoLet al

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Such gastrointestinal effects are a major reason for treatment discontinuation and are intrinsically linked to the mechanisms responsible for the weight loss efficacy of GLP-1RAs