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The National Academies Press

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Over time, factors like sun exposure can cause dark spots and uneven color on the lips

In addition, reduced creatine correlated with nonmodifiable factors, such as male sex and with altered renal function during the follow-up

For example: The STEP 1 trial, published in The New England Journal of Medicine in 2021, found that semaglutide led to significant weight loss and improvements in metabolic markers, with secondary data suggesting modest reductions in lean mass

To avoid redundancy in the subsequent sections, this chapter has summarized the key mechanisms related to selenium, iodine, the Mediterranean diet, and adaptogens