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In a joint letter to the New England Journal of Medicines, the agencies stated that "Both agencies agree that assertions concerning a causal association between incretin-based drugs and pancreatitis or pancreatic cancer, as expressed recently in the scientific literature and in the media, are inconsistent with the current data

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These are mechanistic observations from separate preclinical studies, not outcomes confirmed in combination trials

UAMC-3203 only partially attenuated liver injury by inhibiting the translocation of JNK protein and subsequently reducing mitochondrial damage and liver injury, while ferrostatin-1 demonstrated no protective effect

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11 involved patients with hyperuricaemia or gout, one included those with normal serum urate, and the rest did not distinguish baseline serum urate status