These agents have multiple effects relevant to brain health: improved glycemic control (lowering glucose spikes, avoiding hyperglycemia) weight loss, which reduces many risk factors (vascular disease, hypertension, dyslipidemia) possible reduction of systemic inflammation possible direct neural effects: crossingor affectingthe blood brain barrier
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Safety doesn't translate into humans necessarily," said Brubaker
A.ter HorstK
While we expanded our analysis to include additional follow-up data and performed sensitivity analyses with broader inclusion criteria, we acknowledge that limitations related to sample size remain, particularly for certain subgroup analyses