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Investigation of combination therapies pairing incretin-based agents with other mechanistically distinct therapies may yield additive or synergistic benefits [71]

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Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial

64 SEMA has demonstrated clear clinical improvements in MASLD/MASH and allows use beyond the instructions, particularly in patients with T2DM and obesity

Rather than a drug-specific anomaly, they noted that these trends point to a broader therapeutic role for incretin-based therapies in ocular health, with tirzepatide potentially amplifying this benefit

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