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Originating from harmful and excessive free radicals, a shortage of NRF2 leads to the dysregulation of skin fibroblasts, resulting in reduced collagen I biosynthesis, and diminished collagen fibril deposition 11

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Transcription factors such as sterol regulatory element-binding proteins (SREBPs) and liver X receptors (LXRs) regulate the expression of key enzymes involved in PC synthesis in response to cellular lipid and metabolic status

Similar to microglia and astrocytes, sulforaphane prevents LPS-mediated macrophage activation, inhibiting iNOS expression and NO generation (Heiss et al., 2001)

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It consists of 15 amino acids and is part of a class of compounds known as pentadecapeptides , which have shown remarkable regenerative effects in preclinical studies