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Other extrapyramidal effects reported during clinical trials of topiramate as monotherapy or adjunct therapy of epilepsy in 0.1% to 1% of patients included dyskinesia and dystonic reaction

In the pathological microenvironment of COPD, lipid metabolism undergoes significant reprogramming, characterized by FAO abnormalities, dysregulated sphingolipid and glycerophospholipid metabolism, and imbalanced regulation of triacylglycerol (TAG) and phospholipid synthesis

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We observed good concordance of major cell types at the C12 annotation level between our data and both the Hes 53 and Ludwig 54 datasets