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These heterogenous results stem from the lack of consistent study parameters

PMCID: PMC9133463

17 Saxagliptin is a reversible, potent inhibitor that is selective for DPP-4 by more than 4,000-fold, compared with sitagliptin, whose selectivity is more than 2,600-fold

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"We also have to bring people back to a sense of what the real utilization of these medications is for, and that's for overall health, and not just certain types of looks," he said.

This mechanism is central to how GLP-1 drugs reduce appetite and support weight loss