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Extracellular glutamate levels, which can counteract xCT-mediated cystine uptake, were enriched in the TIF compared to serum (Extended Data Fig

The thyroid contains high amounts of selenium, and a deficiency can lead to thyroid dysfunction (2)

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Advanced Protocol For patients who have completed an introductory phase and are ready for more intensive mitochondrial support: Dose: 10 mg per injection (or as physician-directed) Frequency: 5x per week Duration: ongoing with quarterly physician evaluation Administration: subcutaneous, rotating between abdomen and thigh Monitoring: energy markers, exercise recovery metrics, physician assessment at 8 to 12 weeks Considerations: physician oversight required for advanced dosing